中药药效物质基础研究方法进展

张王宁,李爱平,李科,秦雪梅

中国药学杂志 ›› 2018, Vol. 53 ›› Issue (10) : 761-764.

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中国药学杂志
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中国药学杂志 ›› 2018, Vol. 53 ›› Issue (10) : 761-764. DOI: 10.11669/cpj.2018.10.001
综述

中药药效物质基础研究方法进展

  • 张王宁,李爱平,李科,秦雪梅*
作者信息 +

Progress on Pharmacodynamic Material Basic of Traditional Chinese Medicine

  • ZHANG Wang-ning, LI Ai-ping, LI Ke, QIN Xue-mei*
Author information +
文章历史 +

摘要

中药具有多成分、多靶点、多途径的特色和复杂性。中药药效物质基础研究是阐释中药整体功效及作用本质的核心环节,现阶段中药药效物质基础研究方法主要包括基于中药体内药效活性追踪的有效部位寻找、配伍与拆方研究,基于多种仪器联用表征的化学指纹图谱与效应关联研究,基于体内代谢过程的血清药物化学与方证代谢组学研究,基于体外模型生物活性发现的细胞膜色谱与仿生技术研究,以及基于计算机模拟的网络药理学研究等方法。笔者通过查阅近几年的文献,对该领域的研究方法进行归纳总结,旨在对中药复方药效物质基础研究方法提供理论依据。

Abstract

Traditional Chinese medicine(TCM) has the characteristics and complexities of multi-component, multi-target and multi-way. The study of TCM compound efficacy material basis is the core part in illuminating the effect and mechanism of TCM. So many methods were involved in the researches on material foundation including the effective part searching, compatibility and its disassembled prescriptions investigating based on pharmacological activity tracking in vivo; the association analysis between chemical fingerprints characterized by a variety of instruments and efficacy; serum pharmacochemistry and Chinmedomics based on metabolic processes in vivo; cell membrane chromatography and bionic technology based on activity discovering in vitro; and network pharmacology based on the computer simulation. The paper summarized the research methods in this field by consulting and concluding some document data of recent years, aiming to provide a theoretical foundation for studying on the effective material foundation of compound prescription of traditional Chinese medicine.

关键词

中药 / 复方 / 物质基础 / 研究方法

Key words

Chinese medicine / compound / material foundation / research method

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导出引用
张王宁,李爱平,李科,秦雪梅. 中药药效物质基础研究方法进展[J]. 中国药学杂志, 2018, 53(10): 761-764 https://doi.org/10.11669/cpj.2018.10.001
ZHANG Wang-ning, LI Ai-ping, LI Ke, QIN Xue-mei. Progress on Pharmacodynamic Material Basic of Traditional Chinese Medicine[J]. Chinese Pharmaceutical Journal, 2018, 53(10): 761-764 https://doi.org/10.11669/cpj.2018.10.001
中图分类号： R965    R285   

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基金

国家自然科学基金项目资助(31570346); 黄芪生长年限与化学成分积累规律研究资助(201605D211030);山西省中药产业重点科技攻关项目资助:道地药材种质资源与规范化生产技术研究资助(201603D311101); 山西省药材行业标准-恒山黄芪药材与精品饮片商品等级标准研究资助(2014ZD0401)
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